DHRS4

Dehydrogenase/reductase (SDR family) member 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3O4R​
Identifiers
Symbols	DHRS4 ; CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2
External IDs	OMIM: 611596 MGI: 90169 HomoloGene: 49646 GeneCards: DHRS4 Gene
EC number	1.1.1.184
Gene ontology Molecular function • 3-keto sterol reductase activity • carbonyl reductase (NADPH) activity • receptor binding • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • alcohol dehydrogenase [NAD(P)+ activity] Cellular component • nucleus • mitochondrion • peroxisome • peroxisomal membrane • endoplasmic reticulum membrane • nuclear membrane • intracellular membrane-bounded organelle • extracellular exosome Biological process • alcohol metabolic process • steroid metabolic process • cellular ketone metabolic process • protein tetramerization • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10901	28200
Ensembl	ENSG00000157326	ENSMUSG00000022210
UniProt	Q9BTZ2	Q99LB2
RefSeq (mRNA)	NM_001282987	NM_001037938
RefSeq (protein)	NP_001269916	NP_001033027
Location (UCSC)	Chr 14: 23.95 – 23.97 Mb	Chr 14: 55.48 – 55.49 Mb
PubMed search

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.^[1][2][3]

References

1. Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. PMC 1220285. PMID 10333503.
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
3. "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

Further reading

• Song XH, Liang B, Liu GF, et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Du J, Huang DY, Liu GF, et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao 31 (7): 661–7. PMID 15473316.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.