DISC2

Disrupted in schizophrenia 2 (non-protein coding)
Identifiers
Symbols	DISC2 ; DISC1-AS1; DISC1OS; NCRNA00015
External IDs	OMIM: 606271 GeneCards: DISC2 Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	27184	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is long non-coding RNA. In humans it is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia.^[1] It is antisense to the DISC1 gene and may regulate the expression of DISC1.^[1][2] DISC2 may also contribute to other psychiatric disorders.^[2][3]

See also

• Long noncoding RNA

References

1. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ (May 2000). "Disruption of two novel genes by a translocation co-segregating with schizophrenia". Human Molecular Genetics 9 (9): 1415–23. doi:10.1093/hmg/9.9.1415. PMID 10814723.
2. Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine 36 (5): 367–78. doi:10.1080/07853890410033603. PMID 15478311.
3. Hodgkinson CA, Goldman D, Jaeger J, Persaud S, Kane JM, Lipsky RH, Malhotra AK (Nov 2004). "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder". American Journal of Human Genetics 75 (5): 862–72. doi:10.1086/425586. PMC 1182115. PMID 15386212.

Further reading

• Kato T (Jun 2001). "Molecular genetics of bipolar disorder". Neuroscience Research 40 (2): 105–13. doi:10.1016/s0168-0102(01)00221-8. PMID 11377748.
• Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (Aug 2001). "Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family". American Journal of Human Genetics 69 (2): 428–33. doi:10.1086/321969. PMC 1235314. PMID 11443544.
• Devon RS, Anderson S, Teague PW, Burgess P, Kipari TM, Semple CA, Millar JK, Muir WJ, Murray V, Pelosi AJ, Blackwood DH, Porteous DJ (Jun 2001). "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric Genetics 11 (2): 71–8. doi:10.1097/00041444-200106000-00003. PMID 11525420.
• Taylor MS, Devon RS, Millar JK, Porteous DJ (Jan 2003). "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics 81 (1): 67–77. doi:10.1016/S0888-7543(02)00026-5. PMID 12573262.
• Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine 36 (5): 367–78. doi:10.1080/07853890410033603. PMID 15478311.
• Farmer A, Elkin A, McGuffin P (Jan 2007). "The genetics of bipolar affective disorder". Current Opinion in Psychiatry 20 (1): 8–12. doi:10.1097/YCO.0b013e3280117722. PMID 17143075.
• Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK (Jan 2008). "The DISC locus in psychiatric illness". Molecular Psychiatry 13 (1): 36–64. doi:10.1038/sj.mp.4002106. PMID 17912248.
• Williams JM, Beck TF, Pearson DM, Proud MB, Cheung SW, Scott DA (Aug 2009). "A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder". American Journal of Medical Genetics. Part A 149A (8): 1758–62. doi:10.1002/ajmg.a.32941. PMC 2909829. PMID 19606485.