DIXDC1

DIX domain containing 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3PZ7​
Identifiers
Symbols	DIXDC1 ; CCD1
External IDs	OMIM: 610493 MGI: 2679721 HomoloGene: 82369 GeneCards: DIXDC1 Gene
Gene ontology Molecular function • actin binding • protein binding • protein domain specific binding • gamma-tubulin binding Cellular component • cytosol • focal adhesion Biological process • cell cycle • cerebral cortex radially oriented cell migration • forebrain ventricular zone progenitor cell division • regulation of actin cytoskeleton organization • negative regulation of neuron differentiation • regulation of JNK cascade • canonical Wnt signaling pathway • regulation of microtubule cytoskeleton organization • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	85458	330938
Ensembl	ENSG00000150764	ENSMUSG00000032064
UniProt	Q155Q3	Q80Y83
RefSeq (mRNA)	NM_001037954	NM_178118
RefSeq (protein)	NP_001033043	NP_835219
Location (UCSC)	Chr 11: 111.93 – 112.02 Mb	Chr 9: 50.66 – 50.74 Mb
PubMed search

Dixin is a protein that in humans is encoded by the DIXDC1 gene.^[1][2] When active it stops cancer metastasis due to extreme stickyness, both in vitro and in vivo.^[3]

References

1. Katoh M, Katoh M (Jun 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". Int J Oncol 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID 12792787.
2. "Entrez Gene: DIXDC1 DIX domain containing 1".
3. http://medicalxpress.com/news/2014-07-gene-deadly-cancer.html#nRlv

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ohira M, Morohashi A, Inuzuka H, et al. (2003). "Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets". Oncogene 22 (35): 5525–36. doi:10.1038/sj.onc.1206853. PMID 12934113.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wong CK, Luo W, Deng Y, et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". J. Biol. Chem. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang X, Zheng L, Zeng Z, et al. (2006). "DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein". Biochem. Biophys. Res. Commun. 347 (1): 22–30. doi:10.1016/j.bbrc.2006.06.050. PMID 16814745.