DLGAP2

Discs, large (Drosophila) homolog-associated protein 2
Identifiers
Symbols	DLGAP2 ; DAP2; SAPAP2
External IDs	OMIM: 605438 MGI: 2443181 HomoloGene: 3484 GeneCards: DLGAP2 Gene
Gene ontology Molecular function • protein binding Cellular component • neurofilament • postsynaptic density • cell junction • postsynaptic membrane Biological process • neuron-neuron synaptic transmission Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9228	244310
Ensembl	ENSG00000198010	ENSMUSG00000047495
UniProt	Q9P1A6	Q8BJ42
RefSeq (mRNA)	NM_001277161	NM_001145965
RefSeq (protein)	NP_001264090	NP_001139437
Location (UCSC)	Chr 8: 1.5 – 1.71 Mb	Chr 8: 14.1 – 14.85 Mb
PubMed search

Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene.^[1][2][3]

Function

The product of this gene is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules expressed at various submembrane domains and contain the PDZ, SH3 and the guanylate kinase domains. This protein may play a role in the molecular organization of synapses and in neuronal cell signaling. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length nature is not known.^[3]

Interactions

DLGAP2 has been shown to interact with DLG4, the canonical synapse marker protein, which in turn binds to N-methyld-aspartate (NMDA) receptors and Shaker-type K+ channels.^[4]

Clinical significance

As with many other synaptic genes, including its binding partner Shank2, DLGAP2 has been shown to be associated with Autism.^[5]

References

1. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T (Oct 1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells 2 (6): 415–24. doi:10.1046/j.1365-2443.1997.1310329.x. PMID 9286858.
2. Ranta S, Zhang Y, Ross B, Takkunen E, Hirvasniemi A, de la Chapelle A, Gilliam TC, Lehesjoki AE (Sep 2000). "Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation". Eur J Hum Genet 8 (5): 381–4. doi:10.1038/sj.ejhg.5200440. PMID 10854099.
3. "Entrez Gene: DLGAP2 discs, large (Drosophila) homolog-associated protein 2".
4. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
5. Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R; et al. (2010). "Functional impact of global rare copy number variation in autism spectrum disorders.". Nature 466 (7304): 368–72. doi:10.1038/nature09146. PMC 3021798. PMID 20531469.

Further reading

• Takeuchi M, Hata Y, Hirao K; et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
• Naisbitt S, Kim E, Weinberg RJ; et al. (1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90". J. Neurosci. 17 (15): 5687–96. PMID 9221768.
• Ranta S, Lehesjoki AE, de Fatima Bonaldo M; et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p". Genome Res. 7 (9): 887–96. doi:10.1101/gr.7.9.887. PMID 9314494.
• Hirao K, Hata Y, Ide N; et al. (1998). "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins". J. Biol. Chem. 273 (33): 21105–10. doi:10.1074/jbc.273.33.21105. PMID 9694864.
• Kawabe H, Hata Y, Takeuchi M; et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)". J. Biol. Chem. 274 (43): 30914–8. doi:10.1074/jbc.274.43.30914. PMID 10521485.
• Hirao K, Hata Y, Deguchi M; et al. (2000). "Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments". Genes Cells 5 (3): 203–10. doi:10.1046/j.1365-2443.2000.00318.x. PMID 10759891.
• Wang P, Zhang Q, Tochio H; et al. (2000). "Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution". Eur. J. Biochem. 267 (11): 3116–22. doi:10.1046/j.1432-1327.2000.01318.x. PMID 10824095.
• Bolliger MF, Frei K, Winterhalter KH, Gloor SM (2001). "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression". Biochem. J. 356 (Pt 2): 581–8. doi:10.1042/0264-6021:3560581. PMC 1221872. PMID 11368788.
• Hu LA, Chen W, Premont RT; et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
• Ohtakara K, Nishizawa M, Izawa I; et al. (2003). "Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1". Genes Cells 7 (11): 1149–60. doi:10.1046/j.1365-2443.2002.00589.x. PMID 12390249.
• Verhoeven K, De Jonghe P, Van de Putte T; et al. (2003). "Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10". Am. J. Hum. Genet. 73 (4): 926–32. doi:10.1086/378159. PMC 1180612. PMID 14508709.
• Ying Z, Bingaman W, Najm IM (2004). "Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia". Epilepsia 45 (4): 314–21. doi:10.1111/j.0013-9580.2004.37703.x. PMID 15030493.