DLX1

Distal-less homeobox 1
Identifiers
Symbol	DLX1
External IDs	OMIM: 600029 MGI: 94901 HomoloGene: 22558 GeneCards: DLX1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • chromatin binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • proximal/distal pattern formation • subpallium development • hippocampus development • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment • cerebral cortex GABAergic interneuron fate commitment • odontogenesis of dentin-containing tooth • negative regulation of neuron apoptotic process • negative regulation of Notch signaling pathway • embryonic skeletal system development • negative regulation of oligodendrocyte differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1745	13390
Ensembl	ENSG00000144355	ENSMUSG00000041911
UniProt	P56177	Q64317
RefSeq (mRNA)	NM_001038493	NM_010053
RefSeq (protein)	NP_001033582	NP_034183
Location (UCSC)	Chr 2: 172.08 – 172.09 Mb	Chr 2: 71.53 – 71.53 Mb
PubMed search

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.^[1][2]

Function

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.^[2]

References

1. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K; et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
2. = gene&Cmd = ShowDetailView&TermToSearch = 1745 "Entrez Gene: DLX1 distal-less homeobox 1" Check |url= value (help).

Further reading

• Letinic K, Zoncu R, Rakic P (2002). "Origin of GABAergic neurons in the human neocortex.". Nature 417 (6889): 645–9. doi:10.1038/nature00779. PMID 12050665.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chiba S, Takeshita K, Imai Y; et al. (2004). "Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15577–82. doi:10.1073/pnas.2536757100. PMC 307610. PMID 14671321.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhou QP, Le TN, Qiu X; et al. (2004). "Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation.". Nucleic Acids Res. 32 (3): 884–92. doi:10.1093/nar/gkh233. PMC 373381. PMID 14769946.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hamilton SP, Woo JM, Carlson EJ; et al. (2006). "Analysis of four DLX homeobox genes in autistic probands.". BMC Genet. 6: 52. doi:10.1186/1471-2156-6-52. PMC 1310613. PMID 16266434.