DLX6

Distal-less homeobox 6
Identifiers
Symbols	DLX6 ; MGC125282; MGC125283; MGC125284; MGC125285
External IDs	OMIM: 600030 HomoloGene: 87855 GeneCards: DLX6 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus Biological process • skeletal system development • regulation of transcription, DNA-templated • nervous system development • embryonic limb morphogenesis • epithelial cell differentiation • inner ear morphogenesis • anatomical structure formation involved in morphogenesis • positive regulation of epithelial cell proliferation • palate development • head development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1750	13396
Ensembl	ENSG00000006377	ENSMUSG00000029754
UniProt	P56179	P70397
RefSeq (mRNA)	NM_005222	NM_010057
RefSeq (protein)	NP_005213	NP_034187
Location (UCSC)	Chr 7: 97.01 – 97.01 Mb	Chr 6: 6.86 – 6.87 Mb
PubMed search

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.^[1][2]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7.^[2]

References

1. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K; et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
2. "Entrez Gene: DLX6 distal-less homeobox 6".

Further reading

• Crackower MA, Scherer SW, Rommens JM; et al. (1997). "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.". Hum. Mol. Genet. 5 (5): 571–9. doi:10.1093/hmg/5.5.571. PMID 8733122.
• Charité J, McFadden DG, Merlo G; et al. (2001). "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer.". Genes Dev. 15 (22): 3039–49. doi:10.1101/gad.931701. PMC 312822. PMID 11711438.
• Depew MJ, Lufkin T, Rubenstein JL (2002). "Specification of jaw subdivisions by Dlx genes.". Science 298 (5592): 381–5. doi:10.1126/science.1075703. PMID 12193642.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nabi R, Zhong H, Serajee FJ, Huq AH (2004). "No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 119 (1): 98–101. doi:10.1002/ajmg.b.10012. PMID 12707945.
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schüle B, Li HH, Fisch-Kohl C; et al. (2007). "DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency.". Am. J. Hum. Genet. 81 (3): 492–506. doi:10.1086/520063. PMC 1950824. PMID 17701895.