DMBT1

Deleted in malignant brain tumors 1
Identifiers
Symbols	DMBT1 ; GP340; muclin
External IDs	OMIM: 601969 MGI: 106210 HomoloGene: 68990 GeneCards: DMBT1 Gene
Gene ontology Molecular function • scavenger receptor activity • protein binding • signaling pattern recognition receptor activity • zymogen binding • calcium-dependent protein binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • cytoplasm • extrinsic component of membrane • phagocytic vesicle membrane • zymogen granule membrane • extracellular exosome Biological process • inner cell mass cell proliferation • pattern recognition receptor signaling pathway • receptor-mediated endocytosis • protein transport • viral process • epithelial cell differentiation • positive regulation of epithelial cell differentiation • induction of bacterial agglutination • innate immune response • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1755	12945
Ensembl	ENSG00000187908	ENSMUSG00000047517
UniProt	Q9UGM3	Q60997
RefSeq (mRNA)	NM_004406	NM_007769
RefSeq (protein)	NP_004397	NP_031795
Location (UCSC)	Chr 10: 122.56 – 122.64 Mb	Chr 7: 131.03 – 131.12 Mb
PubMed search

Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.^[1][2]

Function

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.^[3]

Interactions

DMBT1 has been shown to interact with Surfactant protein D.^[4][5]

References

1. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A (Oct 1997). "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours". Nat. Genet. 17 (1): 32–9. doi:10.1038/ng0997-32. PMID 9288095.
2. Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Fölsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S (Jun 2007). "Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion". J. Immunol. 178 (12): 8203–11. doi:10.4049/jimmunol.178.12.8203. PMID 17548659.
3. "Entrez Gene: DMBT1 deleted in malignant brain tumors 1".
4. Tino MJ, Wright JR (1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
5. Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.

Further reading

• Kang W, Reid KB (2003). "DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?". FEBS Lett. 540 (1-3): 21–5. doi:10.1016/S0014-5793(03)00217-5. PMID 12681477.
• Robbe C, Paraskeva C, Mollenhauer J, Michalski JC, Sergi C, Corfield A (2005). "DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer". Biochem. Soc. Trans. 33 (Pt 4): 730–2. doi:10.1042/BST0330730. PMID 16042587.
• Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH (1995). "Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25". Oncogene 10 (11): 2243–6. PMID 7784070.
• Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
• Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard GF, Sugimachi K (1999). "Lack of DMBT1 expression in oesophageal, gastric and colon cancers". Br. J. Cancer 79 (2): 211–3. doi:10.1038/sj.bjc.6690035. PMC 2362205. PMID 9888459.
• Tino MJ, Wright JR (1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
• Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905.
• Takeshita H, Sato M, Shiwaku HO, Semba S, Sakurada A, Hoshi M, Hayashi Y, Tagawa Y, Ayabe H, Horii A (1999). "Expression of the DMBT1 gene is frequently suppressed in human lung cancer". Jpn. J. Cancer Res. 90 (9): 903–8. doi:10.1111/j.1349-7006.1999.tb00833.x. PMID 10551316.
• Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF, Poustka A (1999). "The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability". Oncogene 18 (46): 6233–40. doi:10.1038/sj.onc.1203071. PMID 10597221.
• Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frängsmyr L, Holmskov U, Leffler H, Nilsson C, Borén T, Wright JR, Strömberg N, Fisher SJ (2000). "Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340". J. Biol. Chem. 275 (51): 39860–6. doi:10.1074/jbc.M006928200. PMID 11007786.
• Ma JF, Takito J, Vijayakumar S, Peehl DM, Olsson CA, Al-Awqati Q (2001). "Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation". Prostate 49 (1): 9–18. doi:10.1002/pros.1113. PMID 11550206.
• Ligtenberg TJ, Bikker FJ, Groenink J, Tornoe I, Leth-Larsen R, Veerman EC, Nieuw Amerongen AV, Holmskov U (2001). "Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340". Biochem. J. 359 (Pt 1): 243–8. doi:10.1042/0264-6021:3590243. PMC 1222141. PMID 11563989.
• Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Gröne HJ, Poustka A (2001). "Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer". Cancer Res. 61 (24): 8880–6. PMID 11751412.
• Bikker FJ, Ligtenberg AJ, van der Wal JE, van den Keijbus PA, Holmskov U, Veerman EC, Nieuw Amerongen AV (2002). "Immunohistochemical detection of salivary agglutinin/gp-340 in human parotid, submandibular, and labial salivary glands". J. Dent. Res. 81 (2): 134–9. doi:10.1177/154405910208100210. PMID 11829014.
• Sasaki H, Betensky RA, Cairncross JG, Louis DN (2002). "DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis". Cancer Res. 62 (6): 1790–6. PMID 11912156.
• Schulz BL, Oxley D, Packer NH, Karlsson NG (2002). "Identification of two highly sialylated human tear-fluid DMBT1 isoforms: the major high-molecular-mass glycoproteins in human tears". Biochem. J. 366 (Pt 2): 511–20. doi:10.1042/BJ20011876. PMC 1222789. PMID 12015815.
• Bikker FJ, Ligtenberg AJ, Nazmi K, Veerman EC, van't Hof W, Bolscher JG, Poustka A, Nieuw Amerongen AV, Mollenhauer J (2002). "Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily". J. Biol. Chem. 277 (35): 32109–15. doi:10.1074/jbc.M203788200. PMID 12050164.
• Fan X, Muñoz J, Sanko SG, Castresana JS (2002). "PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas". Int. J. Oncol. 21 (3): 667–74. doi:10.3892/ijo.21.3.667. PMID 12168116.
• Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A (2002). "Rare mutations of the DMBT1 gene in human astrocytic gliomas". Oncogene 21 (38): 5956–9. doi:10.1038/sj.onc.1205733. PMID 12185598.