DNASE1L3

Deoxyribonuclease I-like 3
Identifiers
Symbols DNASE1L3 ; DHP2; DNAS1L3; LSD; SLEB16
External IDs OMIM: 602244 MGI: 1314633 HomoloGene: 3630 ChEMBL: 1649048 GeneCards: DNASE1L3 Gene
EC number 3.1.21.-
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1776 13421
Ensembl ENSG00000163687 ENSMUSG00000025279
UniProt Q13609 O55070
RefSeq (mRNA) NM_001256560 NM_007870
RefSeq (protein) NP_001243489 NP_031896
Location (UCSC) Chr 3:
58.19 – 58.21 Mb
Chr 14:
7.96 – 7.99 Mb
PubMed search

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.[1][2][3][4]

This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[4]

References

  1. Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
  2. Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
  3. Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506.
  4. 1 2 "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".

Further reading

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