DNA polymerase nu

Polymerase (DNA directed) nu
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4XVI​, 4XVK​, 4XVL​, 4XVM​
Identifiers
Symbols	POLN ; POL4P
External IDs	OMIM: 610887 HomoloGene: 129696 GeneCards: POLN Gene
EC number	2.7.7.7
Gene ontology Molecular function • DNA binding • DNA-directed DNA polymerase activity • protein binding • cyclin binding Cellular component • nucleus • nucleoplasm • nucleolus • intracellular membrane-bounded organelle Biological process • double-strand break repair via homologous recombination • DNA-dependent DNA replication • translesion synthesis • interstrand cross-link repair Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353497	272158
Ensembl	ENSG00000130997	ENSMUSG00000045102
UniProt	Q7Z5Q5	Q7TQ07
RefSeq (mRNA)	NM_181808	NM_181857.3
RefSeq (protein)	NP_861524	NP_862905.1
Location (UCSC)	Chr 4: 2.07 – 2.24 Mb	Chr 5: 34.35 – 34.51 Mb
PubMed search

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. ^[1] It is a family A DNA polymerase.^[2]

References

1. "Entrez Gene: Polymerase (DNA directed) nu". Retrieved 2012-05-03.
2. Marini, F.; Kim, N; Schuffert, A; Wood, RD (4 June 2003). "POLN, a Nuclear PolA Family DNA Polymerase Homologous to the DNA Cross-link Sensitivity Protein Mus308". Journal of Biological Chemistry 278 (34): 32014–32019. doi:10.1074/jbc.M305646200. PMID 12794064.

Further reading

• Zietlow, L.; Smith, L. A.; Bessho, M.; Bessho, T. (2009). "Evidence for the Involvement of Human DNA Polymerase N in the Repair of DNA Interstrand Cross-Links". Biochemistry 48 (49): 11817–11824. doi:10.1021/bi9015346. PMC 2790558. PMID 19908865.
• Bi, X.; Barkley, L. R.; Slater, D. M.; Tateishi, S.; Yamaizumi, M.; Ohmori, H.; Vaziri, C. (2006). "Rad18 Regulates DNA Polymerase and is Required for Recovery from S-Phase Checkpoint-Mediated Arrest". Molecular and Cellular Biology 26 (9): 3527–3540. doi:10.1128/MCB.26.9.3527-3540.2006. PMC 1447421. PMID 16611994.
• Moldovan, G. -L.; Madhavan, M. V.; Mirchandani, K. D.; McCaffrey, R. M.; Vinciguerra, P.; d'Andrea, A. D. (2009). "DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination". Molecular and Cellular Biology 30 (4): 1088–1096. doi:10.1128/MCB.01124-09. PMC 2815579. PMID 19995904.
• Marini, F.; Kim, N.; Schuffert, A.; Wood, R. D. (2003). "POLN, a Nuclear PolA Family DNA Polymerase Homologous to the DNA Cross-link Sensitivity Protein Mus308". Journal of Biological Chemistry 278 (34): 32014–32019. doi:10.1074/jbc.M305646200. PMID 12794064.
• Arana, M. E.; Takata, K. I.; Garcia-Diaz, M.; Wood, R. D.; Kunkel, T. A. (2007). "A unique error signature for human DNA polymerase ν". DNA Repair 6 (2): 213–223. doi:10.1016/j.dnarep.2006.09.012. PMC 1950682. PMID 17118716.
• Gohler, T.; Sabbioneda, S.; Green, C. M.; Lehmann, A. R. (2011). "ATR-mediated phosphorylation of DNA polymerase is needed for efficient recovery from UV damage". The Journal of Cell Biology 192 (2): 219–227. doi:10.1083/jcb.201008076. PMC 3172178. PMID 21242293.
• Yamanaka, K.; Minko, I. G.; Takata, K. I.; Kolbanovskiy, A.; Kozekov, I. D.; Wood, R. D.; Rizzo, C. J.; Lloyd, R. S. (2010). "Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links". Chemical Research in Toxicology 23 (3): 689–695. doi:10.1021/tx900449u. PMC 2838406. PMID 20102227.
• Arana, M. E.; Potapova, O.; Kunkel, T. A.; Joyce, C. M. (2011). "Kinetic Analysis of the Unique Error Signature of Human DNA Polymerase ν". Biochemistry 50 (46): 10126–10135. doi:10.1021/bi201197p. PMC 3235957. PMID 22008035.