DNA topoisomerase

DNA topoisomerase
Identifiers
EC number 5.99.1.2
CAS number 80449-01-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase, omega-protein, deoxyribonucleate topoisomerase) is an enzyme with systematic name DNA topoisomerase.[1] This enzyme catalyses the following chemical reaction

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining

These enzymes bring about the conversion of one topological isomer of DNA into another.

References

  1. Gellert, M. (1981). "DNA topoisomerases". Annu. Rev. Biochem. 50: 879–910. doi:10.1146/annurev.bi.50.070181.004311. PMID 6267993.

See also

External links

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