DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

Rendering based on PDB 2PV0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DNMT3L ; MGC1090
External IDs OMIM: 606588 MGI: 1859287 HomoloGene: 8362 GeneCards: DNMT3L Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 29947 54427
Ensembl ENSG00000142182 ENSMUSG00000000730
UniProt Q9UJW3 Q9CWR8
RefSeq (mRNA) NM_013369 NM_001081695
RefSeq (protein) NP_037501 NP_001075164
Location (UCSC) Chr 21:
44.25 – 44.26 Mb
Chr 10:
78.04 – 78.06 Mb
PubMed search

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene.[1][2]

Function

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.[2]

Interactions

DNMT3L has been shown to interact with HDAC1.[3][4]

References

  1. Aapola U, Kawasaki K, Scott HS, Ollila J, Vihinen M, Heino M, Shintani A, Kawasaki K, Minoshima S, Krohn K, Antonarakis SE, Shimizu N, Kudoh J, Peterson P (August 2000). "Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family". Genomics 65 (3): 293–8. doi:10.1006/geno.2000.6168. PMID 10857753.
  2. 1 2 "Entrez Gene: DNMT3L DNA (cytosine-5-)-methyltransferase 3-like".
  3. Aapola U, Liiv I, Peterson P (2002). "Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity". Nucleic Acids Res. 30 (16): 3602–8. doi:10.1093/nar/gkf474. PMC 134241. PMID 12177302.
  4. Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F (September 2002). "Dnmt3L is a transcriptional repressor that recruits histone deacetylase". Nucleic Acids Res. 30 (17): 3831–8. doi:10.1093/nar/gkf509. PMC 137431. PMID 12202768.

Further reading


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