DOC2A

Double C2-like domains, alpha
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4MJJ​
Identifiers
Symbols	DOC2A ; Doc2
External IDs	OMIM: 604567 MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding Cellular component • lysosome • plasma membrane • cell junction • synaptic vesicle membrane • neuron projection Biological process • synaptic transmission • nervous system development • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8448	13446
Ensembl	ENSG00000149927	ENSMUSG00000052301
UniProt	Q14183	Q7TNF0
RefSeq (mRNA)	NM_001282062	NM_010069
RefSeq (protein)	NP_001268991	NP_034199
Location (UCSC)	Chr 16: 30.01 – 30.02 Mb	Chr 7: 126.85 – 126.85 Mb
PubMed search

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.^[1][2][3]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.^[3]

Interactions

DOC2A has been shown to interact with UNC13B^[2][4] and UNC13A.^[5]

References

1. Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
2. Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
3. "Entrez Gene: DOC2A double C2-like domains, alpha".
4. Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
5. "Protein unc-13 homolog A". UniProt.

Further reading

• Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557.
• Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738.
• Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.