DOCK (protein)

Dedicator of cytokinesis
Identifiers
Symbol Ded_cyto
Pfam PF06920
InterPro IPR010703
SCOP 1wg7
SUPERFAMILY 1wg7
CDD cd11684

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence homology:

References

  1. Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.


This article is issued from Wikipedia - version of the Tuesday, February 10, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.