DOT1L

DOT1-like histone H3K79 methyltransferase
PDB rendering based on 1nw3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NW3​, 2MV7​, 3QOW​, 3QOX​, 3SR4​, 3SX0​, 3UWP​, 4EK9​, 4EKG​, 4EKI​, 4EQZ​, 4ER0​, 4ER3​, 4ER5​, 4ER6​, 4ER7​, 4HRA​, 4WVL​
Identifiers
Symbols	DOT1L ; DOT1; KMT4
External IDs	OMIM: 607375 MGI: 2143886 HomoloGene: 32779 ChEMBL: 1795117 GeneCards: DOT1L Gene
EC number	2.1.1.43
Gene ontology Molecular function • DNA binding • protein binding • transcription factor binding • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H3-K79 specific) Cellular component • nucleoplasm Biological process • chromatin organization • chromatin silencing • histone H3-K79 methylation • regulation of JAK-STAT cascade • regulation of cell cycle • regulation of transcription regulatory region DNA binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84444	208266
Ensembl	ENSG00000104885	ENSMUSG00000061589
UniProt	Q8TEK3	Q6XZL8
RefSeq (mRNA)	NM_032482	NM_199322
RefSeq (protein)	NP_115871	NP_955354
Location (UCSC)	Chr 19: 2.16 – 2.23 Mb	Chr 10: 80.76 – 80.8 Mb
PubMed search

DOT1-like, histone H3 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.^[1]

References

1. "Entrez Gene: DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae)".

Further reading

• Nagase T, Nakayama M, Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Feng Q, Wang H, Ng HH; et al. (2002). "Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.". Curr. Biol. 12 (12): 1052–8. doi:10.1016/S0960-9822(02)00901-6. PMID 12123582.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Min J, Feng Q, Li Z; et al. (2003). "Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.". Cell 112 (5): 711–23. doi:10.1016/S0092-8674(03)00114-4. PMID 12628190.
• Jikuya H, Takano J, Kikuno R; et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Okada Y, Feng Q, Lin Y; et al. (2005). "hDOT1L links histone methylation to leukemogenesis.". Cell 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025.
• Sistayanarain A, Tsuneyama K, Zheng H; et al. (2006). "Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma.". Anticancer Res. 26 (5A): 3585–93. PMID 17094487.