DPYSL2

Dihydropyrimidinase-like 2
PDB rendering based on 2gse.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GSE​, 2VM8​
Identifiers
Symbols	DPYSL2 ; CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2
External IDs	OMIM: 602463 MGI: 1349763 HomoloGene: 74392 GeneCards: DPYSL2 Gene
Gene ontology Molecular function • dihydropyrimidinase activity • protein binding • microtubule binding • protein kinase binding Cellular component • mitochondrion • cytosol • microtubule • membrane • dendrite • growth cone • neuronal cell body • terminal bouton • myelin sheath • extracellular exosome Biological process • response to amphetamine • nucleobase-containing compound metabolic process • endocytosis • cytoskeleton organization • signal transduction • nervous system development • axon guidance • positive regulation of glutamate secretion • spinal cord development • olfactory bulb development • regulation of axon extension • response to cocaine • response to drug • synaptic vesicle transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1808	12934
Ensembl	ENSG00000092964	ENSMUSG00000022048
UniProt	Q16555	O08553
RefSeq (mRNA)	NM_001197293	NM_009955
RefSeq (protein)	NP_001184222	NP_034085
Location (UCSC)	Chr 8: 26.51 – 26.66 Mb	Chr 14: 66.8 – 66.87 Mb
PubMed search

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.^[1][2]

Interactions

DPYSL2 has been shown to interact with CRMP1,^[3] Adaptor-related protein complex 2, alpha 1^[4] and NUMB.^[4]

References

1. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
2. "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
3. Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. (Netherlands) 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.
4. Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. (England) 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995). "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33". Nature 376 (6540): 509–14. doi:10.1038/376509a0. PMID 7637782.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Roberts RG, Freeman TC, Kendall E; et al. (1996). "Characterization of DRP2, a novel human dystrophin homologue". Nat. Genet. 13 (2): 223–6. doi:10.1038/ng0696-223. PMID 8640231.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kitamura K, Takayama M, Hamajima N; et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene". DNA Res. 6 (5): 291–7. doi:10.1093/dnares/6.5.291. PMID 10574455.
• Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522". Biochemistry 39 (15): 4267–75. doi:10.1021/bi992323h. PMID 10757975.
• Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules". J. Biol. Chem. 275 (24): 17917–20. doi:10.1074/jbc.C000179200. PMID 10770920.
• Arimura N, Inagaki N, Chihara K; et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse". J. Biol. Chem. 275 (31): 23973–80. doi:10.1074/jbc.M001032200. PMID 10818093.
• Fukada M, Watakabe I, Yuasa-Kawada J; et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
• Santolini E, Puri C, Salcini AE; et al. (2001). "Numb Is an Endocytic Protein". J. Cell Biol. 151 (6): 1345–52. doi:10.1083/jcb.151.6.1345. PMC 2190585. PMID 11121447.
• Lee S, Kim JH, Lee CS; et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937.
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 95–107. doi:10.1007/978-3-7091-6262-0_8. PMID 11771764.
• Fukata Y, Itoh TJ, Kimura T; et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID 12134159.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Leung T, Ng Y, Cheong A; et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610.
• Nishimura T, Fukata Y, Kato K; et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088.
• Nakata K, Ujike H, Tanaka Y; et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans". Neurosci. Lett. 349 (3): 171–4. doi:10.1016/S0304-3940(03)00824-3. PMID 12951196.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.