DRG2

Developmentally regulated GTP binding protein 2
Identifiers
Symbol	DRG2
External IDs	OMIM: 602986 MGI: 1342307 HomoloGene: 1061 GeneCards: DRG2 Gene
Gene ontology Molecular function • protein binding • GTP binding Cellular component • cytoplasm • mitochondrion • membrane Biological process • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1819	13495
Ensembl	ENSG00000108591	ENSMUSG00000020537
UniProt	P55039	Q9QXB9
RefSeq (mRNA)	NM_001388	NM_021354
RefSeq (protein)	NP_001379	NP_067329
Location (UCSC)	Chr 17: 18.09 – 18.11 Mb	Chr 11: 60.45 – 60.47 Mb
PubMed search

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.^[1][2][3]

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.^[3]

References

1. Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet 79 (3–4): 274–5. doi:10.1159/000134741. PMID 9605870.
2. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem 269 (41): 25447–53. PMID 7929244.
3. "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2".

Further reading

• Sprang SR (1998). "G proteins, effectors and GAPs: structure and mechanism". Curr. Opin. Struct. Biol. 7 (6): 849–56. doi:10.1016/S0959-440X(97)80157-1. PMID 9434906.
• Liang Y, Wang A, Belyantseva IA, et al. (2000). "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2". Genomics 61 (3): 243–58. doi:10.1006/geno.1999.5976. PMID 10552926.
• Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
• Vlangos CN, Das P, Patel PI, Elsea SH (2000). "Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval". Cytogenet. Cell Genet. 88 (3–4): 283–5. doi:10.1159/000015539. PMID 10828610.
• Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC: 186594. PMID 11997338.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC: 139241. PMID 12477932.
• Song H, Kim SI, Ko MS, et al. (2005). "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis". J. Biochem. 135 (3): 331–5. doi:10.1093/jb/mvh040. PMID 15113831.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC: 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.