DSE (gene)

Dermatan sulfate epimerase
Identifiers
Symbols	DSE ; DSEP; DSEPI; EDSMC2; SART-2; SART2
External IDs	OMIM: 605942 MGI: 2443455 HomoloGene: 8354 GeneCards: DSE Gene
EC number	5.1.3.19
Gene ontology Molecular function • chondroitin-glucuronate 5-epimerase activity Cellular component • Golgi membrane • endoplasmic reticulum • Golgi apparatus • integral component of membrane Biological process • carbohydrate metabolic process • heparan sulfate proteoglycan biosynthetic process • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • chondroitin sulfate biosynthetic process • dermatan sulfate biosynthetic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29940	212898
Ensembl	ENSG00000111817	ENSMUSG00000039497
UniProt	Q9UL01	Q8BLI4
RefSeq (mRNA)	NM_001080976	NM_172508
RefSeq (protein)	NP_001074445	NP_766096
Location (UCSC)	Chr 6: 116.25 – 116.44 Mb	Chr 10: 34.15 – 34.21 Mb
PubMed search

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.^{[1][2][3][4][5]}

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.^[3]

References

1. Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
2. Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.
3. "Entrez Gene: DSE dermatan sulfate epimerase".
4. Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
5. Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.

Further reading

• Nakao M, Shichijo S, Imaizumi T, et al. (2000). "Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL". J. Immunol. 164 (5): 2565–74. doi:10.4049/jimmunol.164.5.2565. PMID 10679095.
• Tanaka S, Tsuda N, Kawano K, et al. (2001). "Expression of tumor-rejection antigens in gynecologic cancers". Jpn. J. Cancer Res. 91 (11): 1177–84. doi:10.1111/j.1349-7006.2000.tb00902.x. PMID 11092984.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.