DTX1

Deltex 1, E3 ubiquitin ligase
Identifiers
Symbols	DTX1 ; hDx-1
External IDs	OMIM: 602582 MGI: 1352744 HomoloGene: 74522 GeneCards: DTX1 Gene
Gene ontology Molecular function • transcription coactivator activity • Notch binding • protein binding • zinc ion binding • ligase activity • SH3 domain binding • ubiquitin protein ligase binding Cellular component • nucleus • cytoplasm • cytosol Biological process • transcription, DNA-templated • transcription from RNA polymerase II promoter • cell surface receptor signaling pathway • Notch signaling pathway • regulation of Notch signaling pathway • glial cell differentiation • protein ubiquitination • negative regulation of T cell differentiation • negative regulation of neuron differentiation • regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1840	14357
Ensembl	ENSG00000135144	ENSMUSG00000029603
UniProt	Q86Y01	Q61010
RefSeq (mRNA)	NM_004416	NM_008052
RefSeq (protein)	NP_004407	NP_032078
Location (UCSC)	Chr 12: 113.06 – 113.1 Mb	Chr 5: 120.68 – 120.71 Mb
PubMed search

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.^[1][2]

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.^[2]

Interactions

DTX1 has been shown to interact with EP300.^[3]

References

1. Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294.
2. "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
3. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.

Further reading

• Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H (May 2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity 18 (5): 675–85. doi:10.1016/S1074-7613(03)00111-0. PMID 12753744.
• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
• Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A (Mar 2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994.
• Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (Feb 2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity 16 (2): 231–43. doi:10.1016/S1074-7613(02)00271-6. PMID 11869684.
• Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
• Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (Feb 2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". International Journal of Developmental Neuroscience 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.
• Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID (Dec 2000). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Human Genetics 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911.
• Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (Jul 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302.
• Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (Aug 1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development 121 (8): 2633–44. PMID 7671825.