DTYMK

Deoxythymidylate kinase (thymidylate kinase)
PDB rendering based on 1e2d.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1E2D​, 1E2E​, 1E2F​, 1E2G​, 1E2Q​, 1E98​, 1E99​, 1E9A​, 1E9B​, 1E9C​, 1E9D​, 1E9E​, 1E9F​, 1NMX​, 1NMY​, 1NMZ​, 1NN0​, 1NN1​, 1NN3​, 1NN5​, 2XX3​
Identifiers
Symbols	DTYMK ; CDC8; PP3731; TMPK; TYMK
External IDs	OMIM: 188345 MGI: 108396 HomoloGene: 6285 ChEMBL: 4388 GeneCards: DTYMK Gene
EC number	2.7.4.9
Gene ontology Molecular function • thymidylate kinase activity • ATP binding • uridylate kinase activity • nucleoside phosphate kinase activity Cellular component • cytoplasm • mitochondrial intermembrane space • mitochondrial matrix • cytosol Biological process • dUDP biosynthetic process • dTDP biosynthetic process • dTTP biosynthetic process • cell cycle • cell proliferation • nucleobase-containing small molecule interconversion • response to estrogen • small molecule metabolic process • myoblast differentiation • response to cadmium ion • nucleotide phosphorylation • nucleoside monophosphate phosphorylation • nucleobase-containing small molecule metabolic process • cellular response to growth factor stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1841	21915
Ensembl	ENSG00000168393	ENSMUSG00000026281
UniProt	P23919	P97930
RefSeq (mRNA)	NM_001165031	NM_001105667
RefSeq (protein)	NP_001158503	NP_001099137
Location (UCSC)	Chr 2: 241.68 – 241.69 Mb	Chr 1: 93.79 – 93.8 Mb
PubMed search

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.^[1][2][3] and belongs to thymidylate kinase family of proteins.

References

1. Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.
2. Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.
3. "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

Further reading

• Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases.". Pharmacol. Ther. 87 (2-3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
• Tamiya N, Yusa T, Yamaguchi Y; et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography.". Biochim. Biophys. Acta 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
• Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.". Cancer Res. 40 (4): 1235–9. PMID 6244089.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ostermann N, Segura-Peña D, Meier C; et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds.". Biochemistry 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.