DYNLRB1

Dynein, light chain, roadblock-type 1

PDB rendering based on 1y4o.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DYNLRB1 ; BITH; BLP; DNCL2A; DNLC2A; ROBLD1
External IDs OMIM: 607167 MGI: 1914318 HomoloGene: 69161 GeneCards: DYNLRB1 Gene
Orthologs
Species Human Mouse
Entrez 83658 67068
Ensembl ENSG00000125971 ENSMUSG00000047459
UniProt Q9NP97 P62627
RefSeq (mRNA) NM_001281727 NM_001291108
RefSeq (protein) NP_001268656 NP_001278037
Location (UCSC) Chr 20:
34.52 – 34.54 Mb
Chr 2:
155.24 – 155.25 Mb
PubMed search

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[1][2][3]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[3]

References

  1. Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132.
  2. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  3. 1 2 "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".

Further reading

This article is issued from Wikipedia - version of the Tuesday, May 05, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.