DYNLT1

Dynein, light chain, Tctex-type 1
Identifiers
Symbols	DYNLT1 ; CW-1; TCTEL1; tctex-1
External IDs	OMIM: 601554 MGI: 98643 HomoloGene: 4754 GeneCards: DYNLT1 Gene
Gene ontology Molecular function • motor activity • protein binding • identical protein binding Cellular component • Golgi apparatus • spindle • cytoplasmic dynein complex • microtubule • host cell Biological process • establishment of mitotic spindle orientation • mitotic nuclear division • metabolic process • regulation of G-protein coupled receptor protein signaling pathway • intracellular transport of viral protein in host cell • regulation of GTPase activity • viral entry into host cell • neuron projection morphogenesis • negative regulation of neurogenesis • cell division • regulation of cytoskeleton organization • microtubule-dependent intracellular transport of viral material towards nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6993	21648
Ensembl	ENSG00000146425	ENSMUSG00000096255
UniProt	P63172	P51807
RefSeq (mRNA)	NM_001291602	NM_009342
RefSeq (protein)	NP_001278531	NP_033368
Location (UCSC)	Chr 6: 158.64 – 158.64 Mb	Chr 17: 6.43 – 6.44 Mb
PubMed search

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^[1][2][3]

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]^[3]

References

1. Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet 73 (1-2): 153–6. doi:10.1159/000134329. PMID 8646886.
2. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
3. "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

Further reading

• Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de médecine de Lyon 52 (192): 1523–6 passim. PMID 5503857.
• King SM, Dillman JF, Benashski SE; et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
• Nagano F, Orita S, Sasaki T; et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691.
• Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301.
• Nadano D, Nakayama J, Matsuzawa S; et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.". Biochem. J. 364 (Pt 3): 669–77. doi:10.1042/BJ20011836. PMC 1222615. PMID 12049630.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Machado RD, Rudarakanchana N, Atkinson C; et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.". Hum. Mol. Genet. 12 (24): 3277–86. doi:10.1093/hmg/ddg365. PMID 14583445.
• Douglas MW, Diefenbach RJ, Homa FL; et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
• Ohka S, Matsuda N, Tohyama K; et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMC 421661. PMID 15194795.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• de Wit NJ, Verschuure P, Kappé G; et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.". Eur. J. Cell Biol. 83 (7): 337–45. doi:10.1078/0171-9335-00396. PMID 15503857.
• Chuang JZ, Yeh TY, Bollati F; et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.". Dev. Cell 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMID 15992542.
• Yeh TY, Peretti D, Chuang JZ; et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.". Traffic 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMID 16956385.