Daniel Haber

For the footballer, see Daniel Haber (soccer).
Daniel A. Haber
Nationality French
Fields Genetics
Institutions Harvard University
Alma mater Massachusetts Institute of Technology, Stanford University
Known for Cancer Genetics

Daniel A. Haber Ph.D., M.D. is the director of Massachusetts General Hospital Cancer Center, a Professor of Oncology at Harvard Medical School, and an investigator of the Howard Hughes Medical Institute (HHMI). He earned his B.S. in Life Sciences and M.S. in toxicology from Massachusetts Institute of Technology, and his M.D. and Ph.D. in biophysics from Stanford University School of Medicine under the mentorship of Robert T. Schimke.[1] He did his postdoctoral training at Massachusetts Institute of Technology with David E. Housman.[2]

As a postdoc, he started to study Wilms' tumor and characterized the tumor suppressor gene WT1 and WTX.[3][4] In 2003, he recognized that certain patients with lung cancer responded well to the drug Iressa where few other patients showed effect. Sequencing the patient's cancers, they identified specific mutation in epidermal growth factor receptor (EGFR) that resulted in sensitivity to certain drugs.[5][6] By linking mutations to drug sensitivity, they were able to propose new mechanisms for targeted therapies by examining the accumulation of certain mutations in cancer cells.[1] His lab is now focused on studying the genetics of cancer particularly in circulating tumor cells with Mehmet Toner.

He is a fellow of the American Academy of Arts and Sciences and a member of the Institute of Medicine, the Association of American Physicians, and the American Society for Clinical Investigation. He is an editor of Cell and Cancer Cell.[2]

External links

References

  1. 1 2 "Daniel A. Haber". HHMI. Retrieved 10 November 2012.
  2. 1 2 "Daniel Haber, M.D., Ph.D.". Retrieved 10 November 2012.
  3. ↑ Haber, DA; Buckler, AJ; Glaser, T; Call, KM; Pelletier, J; Sohn, RL; Douglass, EC; Housman, DE (Jun 29, 1990). "An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.". Cell 61 (7): 1257–69. doi:10.1016/0092-8674(90)90690-g. PMID 2163761.
  4. ↑ "MERIT Award Recipient: Daniel A. Haber, M.D., Ph.D.". Retrieved 10 November 2012.
  5. ↑ Lynch, Thomas J.; Bell, Daphne W.; Sordella, Raffaella; Gurubhagavatula, Sarada; Okimoto, Ross A.; Brannigan, Brian W.; Harris, Patricia L.; Haserlat, Sara M.; Supko, Jeffrey G.; Haluska, Frank G.; Louis, David N.; Christiani, David C.; Settleman, Jeff; Haber, Daniel A. (20 May 2004). "Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib". New England Journal of Medicine 350 (21): 2129–2139. doi:10.1056/NEJMoa040938. PMID 15118073.
  6. ↑ Sordella, R; Bell, DW; Haber, DA; Settleman, J (Aug 20, 2004). "Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.". Science 305 (5687): 1163–7. doi:10.1126/science.1101637. PMID 15284455.


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