Deep Six

Deep Six may refer to:

• "Deep Six", a song from the 1984 Big Black EP Racer-X
• Deep Six (album), a 1986 compilation album
• "Deep Six", a song that appeared on the 1997 album Underdogs by Matthew Good Band
• "Deep Six" (song), a song from the 2015 Marilyn Manson album The Pale Emperor
• Deep Six (novel), a 1984 Dirk Pitt adventure novel by Clive Cussler
• Deep Six (Alberta politics), a group of fiscally conservative members of the Legislative Assembly of Alberta, Canada
• Deep Six (Marvel Comics), two Marvel Comics teams with the same name
• Deep Six (DC Comics), a DC Comics supervillain team
• Deep Six (G.I. Joe), a fictional character in the G.I. Joe universe
• Deep Six, a fictional novel by Timothy McGee, a character in the NCIS universe
• "Deep Six", an episode of Teen Titans
• Deepsix, a science fiction novel by Jack McDevitt
• The Deep Six, a 1958 World War II war film starring Alan Ladd