Endoderm

Endoderm
Organs derived from endoderm.
Details
Days	16
Precursor	hypoblast
Identifiers
MeSH	A16.254.425.407
FMA	69071
Anatomical terminology [edit on Wikidata]

Endoderm is one of the three primary germ layers in the very early human embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer), with the endoderm being the innermost layer.^[1] Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm.

The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of multiple systems.

Production

The following chart shows the tissues produced by the endoderm. The embryonic endoderm develops into the interior linings of two tubes in the body, the digestive and respiratory tube.^[2]

Layer	Category	System
General[3]	Gastrointestinal tract.	the entire alimentary canal except part of the mouth, pharynx and the terminal part of the rectum (which are lined by involutions of the ectoderm), the lining cells of all the glands which open into the digestive tube, including those of the liver and pancreas
General	Respiratory tract	the trachea, bronchi, and alveoli of the lungs
General	Endocrine glands and organs	the lining of the follicles of the thyroid gland and thymus
	Auditory system	the epithelium of the auditory tube and tympanic cavity
	Urinary system	the urinary bladder and part of the urethra

Liver and pancreas cells are believed to derive from a common precursor.^[4]

In humans,the endoderm can differentiate into distinguishable organs after 5 weeks of embryonic development.

Additional images

• 

  Section through the embryo.

• 

  Section through ovum imbedded in the uterine decidua

• 

  Signaling pathway to inducing endoderm

See also

• Ectoderm
• Germ layer
• Histogenesis
• Mesoderm
• Organogenesis
• Endodermal sinus tumor
• Gastrulation

References

This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)

1. Langman's Medical Embryology, 11th edition. 2010.
2. Gilbert, SF. "Endoderm". Sinauer Associates. Retrieved 14 March 2013.
3. The General category denotes that all or most of the animals containing this layer produce the adjacent product.
4. Zaret KS (October 2001). "Hepatocyte differentiation: from the endoderm and beyond". Curr. Opin. Genet. Dev. 11 (5): 568–74. doi:10.1016/S0959-437X(00)00234-3. PMID 11532400.