Delta-like 1

Delta-like 1 (Drosophila)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DLL1 ; DELTA1; DL1; Delta
External IDs OMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 28514 13388
Ensembl ENSG00000198719 ENSMUSG00000014773
UniProt O00548 Q61483
RefSeq (mRNA) NM_005618 NM_007865
RefSeq (protein) NP_005609 NP_031891
Location (UCSC) Chr 6:
170.28 – 170.31 Mb
Chr 17:
15.37 – 15.38 Mb
PubMed search

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2[2][3][4]

References

  1. 1 2 "Entrez Gene: DLL1 delta-like 1 (Drosophila)".
  2. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
  3. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302.
  4. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

Further reading


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