Denaverine

Denaverine

Systematic (IUPAC) name
2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Biological half-life	34 hours
Identifiers
CAS Number	3579-62-2 3321-06-0 (hydrochloride)
ATCvet code	QG02CX90(WHO)
PubChem	CID 71130
ChemSpider	64278
UNII	O14NF38MTL
KEGG	D07787
ChEMBL	CHEMBL1614656
Chemical data
Formula	C24H33NO3
Molar mass	383.52 g/mol
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N
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Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]

References

1. Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
2. Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
3. Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German) 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.