Dermatopathic lymphadenopathy

Micrograph showing dermatopathic lymphadenopathy with the characteristic paracortical histiocytosis and melanin-laden macrophages. H&E stain.

In pathology, dermatopathic lymphadenopathy, also dermatopathic lymphadenitis, is lymph node pathology due to skin disease.

Associations/differential diagnosis

• Cutaneous T cell lymphoma^[1]
• Hodgkin's lymphoma^[1]
• Melanoma

Diagnosis

Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:

• Paracortical histiocytosis
• Melanin-laden macrophages
• Eosinophils
• Plasma cells (medulla of lymph node)

Treatment

The treatment is based on the underlying cause.

See also

• Skin disease
• List of cutaneous conditions

References

1. Lee, SW.; Park, MC.; Kim, H.; Park, YB.; Lee, SK. "Dermatopathic lymphadenopathy in a patient with adult onset Still's disease.". Clin Exp Rheumatol 25 (2): 312–4. PMID 17543161.

External links

• Dermatopathic lymphadenitis - pathconsultddx.com.