Detention center (cell biology)

For other uses, see Detention center.
Cells without (left) and with (right) Detention Centers

A nucleolar detention center (DC) is a region of the cell in which certain proteins are temporarily detained in periods of cellular stress.[1] DCs are absent from cells under normal culture conditions, but form in response to specific environmental triggers, such as low extracellular pH or high temperature, when long noncoding RNAs are induced from regions of intergenic DNA.[1][2][3] The detention of numerous proteins in DCs is believed to reduce metabolic activity and promote survival under unfavorable conditions.[4] DCs form at the center of nucleoli and therefore disrupt the normal organization of these organelles. The structural remodeling that ensues leaves nucleoli unable to sustain their primary function, ribosomal biogenesis. Therefore, the formation of DCs is thought to convert nucleoli from “ribosome factories” to “prisons for proteins”.[1]

References

  1. 1 2 3 Jacob MD, Audas TE, Uniacke J, Trinkle-Mulcahy L, Lee S (2013). "Environmental cues induce a long noncoding RNA-dependent remodeling of the nucleolus". Mol Biol Cell. 25 (18): 2943–53. doi:10.1091/mbc.E13-04-0223. PMC 3771955. PMID 23904269.
  2. ↑ Audas TE, Jacob MD, Lee S (2012). "Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA". Mol Cell. 45 (2): 145–57. doi:10.1016/j.molcel.2011.12.012. PMID 22284675.
  3. ↑ Prasanth KV (2012). "Policing cells under stress: noncoding RNAs capture proteins in nucleolar detention centers". Mol Cell. 45 (2): 141–2. doi:10.1016/j.molcel.2012.01.005. PMID 22284672.
  4. ↑ Audas TE, Jacob MD, Lee S (2012). "The nucleolar detention pathway: a cellular strategy for regulating molecular networks". Cell Cycle. 11 (11): 2059–62. doi:10.4161/cc.20140. PMC 3368857. PMID 22580471.


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