Deuterated drug

A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms contained in the drug molecule have been replaced by deuterium. Because of the kinetic isotope effect, deuterium-containing drugs may have significantly lower rates of metabolism, and hence a longer half-life.[1][2][3] Some examples of deuterated drugs are the psychedelics beta-D and 4-D.

The first patent in the US granted for deuterated molecules was in the 1970s. Since then patents on deuterated drugs have become more prolific.[4]

References

  1. ↑ Sanderson K (2009). "Big interest in heavy drugs". Nature 458 (7236): 269. doi:10.1038/458269a. PMID 19295573.
  2. ↑ Katsnelson A (2013). "Heavy drugs draw heavy interest from pharma backers". Nat. Med. 19 (6): 656. doi:10.1038/nm0613-656. PMID 23744136.
  3. ↑ Gant TG (2014). "Using deuterium in drug discovery: leaving the label in the drug". J. Med. Chem. 57 (9): 3595–611. doi:10.1021/jm4007998. PMID 24294889.
  4. ↑ "Drugs that live long will prosper". The Economist. ISSN 0013-0613. Retrieved 2015-09-18.
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