Dibromotyrosine

Dibromotyrosine
Systematic (IUPAC) name

(2S)-2-Amino-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid
Identifiers
CAS Number	300-38-9^Y
ATC code	H03BX02 (WHO)
PubChem	CID 67532
ChemSpider	60854^N
UNII	QD49LEP46E^Y
ChEBI	CHEBI:28335^N
Chemical data
Formula	C₉H₉Br₂NO₃
Molar mass	338.981 g/mol
SMILES Brc1cc(cc(Br)c1O)C[C@@H](C(=O)O)N
InChI InChI=1S/C9H9Br2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1^N Key:COESHZUDRKCEPA-ZETCQYMHSA-N^N
^NY (what is this?) (verify)

Dibromotyrosine is an antithyroid preparation and a derivative of the natural amino acid tyrosine.

It is formed by eosinophil peroxidase.^[1]

References

↑ Kambayashi Y, Ogino K, Takemoto K; et al. (January 2009). "Preparation and Characterization of a Polyclonal Antibody against Brominated Protein". J Clin Biochem Nutr 44 (1): 95–103. doi:10.3164/jcbn.08-196. PMC 2613505. PMID 19177194.

Thyroid therapy (H03)

Thyroid hormones

Antithyroid preparations

Thyroid peroxidase inhibitors (thioamide)	Thiouracils: Propylthiouracil^# Methylthiouracil Benzylthiouracil Sulfur-containing imidazole derivatives: Carbimazole Methimazole

Block conversion of T4 to T3	Propylthiouracil^# Ipodate

Sodium-iodide symporter inhibitor	Perchlorate (Potassium perchlorate) Pertechnetate (Sodium pertechnetate)

Other	Diiodotyrosine Dibromotyrosine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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