Dichloroarcyriaflavin A synthase

Dichloroarcyriaflavin A synthase
Identifiers
EC number	1.13.12.17
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Dichloroarcyriaflavin A synthase (EC 1.13.12.17) is an enzyme with systematic name dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

dichlorochromopyrrolate + 4 O₂ + 4 NADH + 4 H⁺ $\rightleftharpoons$ dichloroarcyriaflavin A + 2 CO₂ + 6 H₂O + 4 NAD⁺

RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation

References

1. Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H. and Nagano, S. (2007). "Crystal structures and catalytic mechanism of cytochrome P₄₅₀ StaP that produces the indolocarbazole skeleton". Proc. Natl. Acad. Sci. USA 104 (28): 11591–11596. doi:10.1073/pnas.0702946104. PMC 1913897. PMID 17606921.
2. Howard-Jones, A.R. and Walsh, C.T. (2006). "Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid". J. Am. Chem. Soc. 128 (37): 12289–12298. doi:10.1021/ja063898m. PMID 16967980.
3. Sanchez, C., Zhu, L., Brana, A.F., Salas, A.P., Rohr, J., Mendez, C. and Salas, J.A. (2005). "Combinatorial biosynthesis of antitumor indolocarbazole compounds". Proc. Natl. Acad. Sci. USA 102 (2): #461–466. doi:10.1073/pnas.0407809102. PMC 544307. PMID 15625109.

External links

• Dichloroarcyriaflavin A synthase at the US National Library of Medicine Medical Subject Headings (MeSH)