Diminazen

Diminazen

Systematic (IUPAC) name
4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
Clinical data
Trade names	Azidin, Berenil, Ganasag, Pirocide
Routes of administration	IM, SC
Legal status
Legal status	Veterinary
Identifiers
CAS Number	536-71-0 aceturate: 908-54-3
ATCvet code	QP51AF01 (WHO) QP51AX07 (WHO)
PubChem	CID 2354
ChemSpider	2264
UNII	Y5G36EEA5Z aceturate: JI8SAD85NO
ChEBI	CHEBI:81724
ChEMBL	CHEMBL124025
Synonyms	4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide)
Chemical data
Formula	C14H15N7
Molar mass	281.316 g/mol
SMILES C1=CC(=CC=C1C(=N)N)N/N=N/C2=CC=C(C=C2)C(=N)N
InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20) Key:XNYZHCFCZNMTFY-UHFFFAOYSA-N

Diminazen(e) is an anti-infective medication for animals that is sold under a variety of brand names (see drugbox). It is effective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.^[1][2]

Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).

The mechanism is not well understood; it probably inhibits DNA replication,^[1] but also has affinity to RNA.

Side effects

Acute side effects include vomiting, diarrhoea and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; especially camels are susceptible to these effects.^[1]

References

1. Peregrine, A. S.; Mamman, M. (1993). "Pharmacology of diminazene: A review". Acta tropica 54 (3–4): 185–203. doi:10.1016/0001-706X(93)90092-P. PMID 7902657.
2. Mungube, E. O.; Vitouley, H. S.; Allegye-Cudjoe, E.; Diall, O.; Boucoum, Z.; Diarra, B.; Sanogo, Y.; Randolph, T.; Bauer, B.; Zessin, K. H.; Clausen, P. H. (2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors 5: 155. doi:10.1186/1756-3305-5-155. PMC 3432589. PMID 22852796.