Dinoflagellate luciferase

Dinoflagellate luciferase
Identifiers
EC number	1.13.12.18
CAS number	303183-71-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Dinoflagellate luciferase (EC 1.13.12.18, Gonyaulax luciferase) is a specific luciferase, an enzyme with systematic name dinoflagellate-luciferin:oxygen 132-oxidoreductase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

dinoflagellate luciferin + O₂ $\rightleftharpoons$ oxidized dinoflagellate luciferin + H₂O + hnu

Dinoflagellate luciferase is a single protein with three luciferase domains.

References

1. Dunlap, J.C. and Hastings, J.W. (1981). "The biological clock in Gonyaulax controls luciferase activity by regulating turnover". J. Biol. Chem. 256 (20): 10509–10518. PMID 7197271.
2. Morse, D., Pappenheimer, A.M., Jr. and Hastings, J.W. (1989). "Role of a luciferin-binding protein in the circadian bioluminescent reaction of Gonyaulax polyedra". J. Biol. Chem. 264 (20): 11822–11826. PMID 2745419.
3. Bae, Y.M. and Hastings, J.W. (1994). "Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra". Biochim. Biophys. Acta 1219 (2): 449–456. doi:10.1016/0167-4781(94)90071-x. PMID 7918642.
4. Li, L. (2000). "Gonyaulax luciferase: gene structure, protein expression, and purification from recombinant sources". Methods Enzymol. 305: 249–258. doi:10.1016/s0076-6879(00)05492-6. PMID 10812605.
5. Morse, D. and Mittag, M. (2000). "Dinoflagellate luciferin-binding protein". Methods Enzymol. 305: 258–276. doi:10.1016/s0076-6879(00)05493-8. PMID 10812606.
6. Schultz, L.W., Liu, L., Cegielski, M. and Hastings, J.W. (2005). "Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole". Proc. Natl. Acad. Sci. USA 102: 1378–1383. doi:10.1073/pnas.0409335102. PMC 547824. PMID 15665092.

External links

• Dinoflagellate luciferase at the US National Library of Medicine Medical Subject Headings (MeSH)