Dock4-Ex49

Dock4-Ex49 is a splice variant of the signalling protein Dock4 (Dedicator of cytokinesis 4). It has been found in the brain, inner ear and eye.[1] It is able to bind and activate the small G protein Rac and may regulate the organisation of the actin cytoskeleton in the Stereocilia of the inner ear.

References

  1. ↑ Yan D, Li F, Hall ML; et al. (March 2006). "An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C)". J. Mol. Biol. 357 (3): 755–64. doi:10.1016/j.jmb.2006.01.017. PMID 16464467.
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