Dopachrome tautomerase

Dopachrome tautomerase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4HX1​
Identifiers
Symbols	DCT ; TRP-2; TYRP2
External IDs	OMIM: 191275 MGI: 102563 HomoloGene: 1447 GeneCards: DCT Gene
EC number	5.3.3.12
Gene ontology Molecular function • dopachrome isomerase activity • copper ion binding • oxidoreductase activity Cellular component • cytosol • integral component of membrane • melanosome membrane • melanosome Biological process • positive regulation of neuroblast proliferation • melanin biosynthetic process from tyrosine • epidermis development • ventricular zone neuroblast division • cellular nitrogen compound metabolic process • melanin biosynthetic process • small molecule metabolic process • developmental pigmentation • cell development • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1638	13190
Ensembl	ENSG00000080166	ENSMUSG00000022129
UniProt	P40126	P29812
RefSeq (mRNA)	NM_001129889	NM_010024
RefSeq (protein)	NP_001123361	NP_034154
Location (UCSC)	Chr 13: 94.44 – 94.48 Mb	Chr 14: 118.01 – 118.05 Mb
PubMed search

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene.^[1] Its expression is regulated by the microphthalmia-associated transcription factor (MITF).^[2][3]

See also

• Tyrosinase-related protein 1 (TYRP1)

References

1. "Entrez Gene: DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)".
2. Yasumoto K, Takeda K, Saito H; et al. (2002). "Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling". EMBO J. 21 (11): 2703–14. doi:10.1093/emboj/21.11.2703. PMC 126018. PMID 12032083.
3. Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Jackson IJ, Chambers DM, Tsukamoto K; et al. (1992). "A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus". EMBO J. 11 (2): 527–35. PMC 556483. PMID 1537334.
• Tobin D, Quinn AG, Ito S, Thody AJ (1995). "The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type". Pigment Cell Res. 7 (4): 204–9. doi:10.1111/j.1600-0749.1994.tb00050.x. PMID 7855064.
• Bernd A, Ramirez-Bosca A, Kippenberger S; et al. (1995). "Levels of dopachrome tautomerase in human melanocytes cultured in vitro". Melanoma Res. 4 (5): 287–91. doi:10.1097/00008390-199410000-00003. PMID 7858411.
• Yokoyama K, Yasumoto K, Suzuki H, Shibahara S (1994). "Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression". J. Biol. Chem. 269 (43): 27080–7. PMID 7929451.
• Orlow SJ, Zhou BK, Chakraborty AK; et al. (1994). "High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex". J. Invest. Dermatol. 103 (2): 196–201. doi:10.1111/1523-1747.ep12392743. PMID 8040609.
• Sturm RA, Baker E, Sutherland GR (1994). "Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14". Genomics 21 (1): 293–6. doi:10.1006/geno.1994.1266. PMID 8088811.
• Abdel-Malek Z, Swope V, Collins C; et al. (1994). "Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes". J. Cell. Sci. 106 (4): 1323–31. PMID 8126111.
• Yokoyama K, Suzuki H, Yasumoto K; et al. (1994). "Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2". Biochim. Biophys. Acta 1217 (3): 317–21. doi:10.1016/0167-4781(94)90292-5. PMID 8148378.
• Cassady JL, Sturm RA (1994). "Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA". Gene 143 (2): 295–8. doi:10.1016/0378-1119(94)90114-7. PMID 8206391.
• Odh G, Hindemith A, Rosengren AM; et al. (1994). "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole". Biochem. Biophys. Res. Commun. 197 (2): 619–24. doi:10.1006/bbrc.1993.2524. PMID 8267597.
• Bouchard B, Del Marmol V, Jackson IJ; et al. (1994). "Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells". Eur. J. Biochem. 219 (1–2): 127–34. doi:10.1111/j.1432-1033.1994.tb19922.x. PMID 8306979.
• Sturm RA, O'Sullivan BJ, Box NF; et al. (1996). "Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family". Genomics 29 (1): 24–34. doi:10.1006/geno.1995.1211. PMID 8530077.
• Björk P, Aman P, Hindemith A; et al. (1996). "A new enzyme activity in human blood cells and isolation of the responsible protein (D-dopachrome tautomerase) from erythrocytes". Eur. J. Haematol. 57 (3): 254–6. doi:10.1111/j.1600-0609.1996.tb01372.x. PMID 8898931.
• Smith-Thomas L, Richardson P, Thody AJ; et al. (1997). "Human ocular melanocytes and retinal pigment epithelial cells differ in their melanogenic properties in vivo and in vitro". Curr. Eye Res. 15 (11): 1079–91. doi:10.3109/02713689608995139. PMID 8950502.
• Wang RF, Appella E, Kawakami Y; et al. (1997). "Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes". J. Exp. Med. 184 (6): 2207–16. doi:10.1084/jem.184.6.2207. PMC 2211562. PMID 8976176.
• Chi DD, Merchant RE, Rand R; et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas". Am. J. Pathol. 150 (6): 2143–52. PMC 1858329. PMID 9176405.
• Sugimoto H, Taniguchi M, Nakagawa A; et al. (1997). "Crystallization and preliminary X-ray analysis of human D-dopachrome tautomerase". J. Struct. Biol. 120 (1): 105–8. doi:10.1006/jsbi.1997.3904. PMID 9356298.
• Nishihira J, Fujinaga M, Kuriyama T; et al. (1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem. Biophys. Res. Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
• Kippenberger S, Loitsch S, Solano F; et al. (1998). "Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones". J. Invest. Dermatol. 110 (4): 364–7. doi:10.1046/j.1523-1747.1998.00144.x. PMID 9540976.
• Lupetti R, Pisarra P, Verrecchia A; et al. (1998). "Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage". J. Exp. Med. 188 (6): 1005–16. doi:10.1084/jem.188.6.1005. PMC 2212536. PMID 9743519.