Douglas Kell

Douglas Kell
Douglas Kell at Buckingham Palace with Carole Goble after receiving his CBE
Born	Douglas Bruce Kell 7 April 1953[1]
Nationality	United Kingdom
Fields	Systems Biology Computational Biology[2]
Institutions	BBSRC University of Manchester Aberystwyth University University of Oxford
Alma mater	University of Oxford (BA, PhD)
Thesis	The Bioenergetics of Paracoccus denitrificans (1978)
Doctoral advisor	Stuart Ferguson[3] Philip John
Doctoral students	Eva Zelena[4][5] Thomas Williamson[6][7] Adaoha Ihekwaba[8][9][10] Maria Brown[11][12][13] Julia Handl[14][15][16] Pedro Mendes[17]
Known for	CEO of BBSRC
Notable awards	FSB[1] FAAAS (2012)[18] FLSW (2012)[19] CBE (2014)[20]
Spouse	Dr Antje Wagner (m. 1989)[1]
Children	one son, two daughters[1]
Website dbkgroup.org manchester.ac.uk/research/douglas.kell

Douglas Bruce Kell CBE^[20] FLSW (born 7 April 1953) is a British biochemist and Professor of Bioanalytical Sciences in the School of Chemistry at the University of Manchester, based in the Manchester Institute of Biotechnology (MIB).^[21] He was formerly Chief Executive Officer (CEO) of the Biotechnology and Biological Sciences Research Council (BBSRC) from 2008-2013.^{[22][23][24][25][26][27][28][29]}

Education

He was educated at Hydneye House in Sussex,^[30] Bradfield College in Berkshire and St John's College, Oxford. He graduated with a Bachelor of Arts in Biochemistry in 1975 and a Doctor of Philosophy (Oxon) in 1978 with a thesis on the Bioenergetics of Paracoccus denitrificans supervised by Stuart John Ferguson^[3][31] and Philip John.^[32]

From 1978 to 2002 he worked at Aberystwyth University, moving to UMIST in 2002 as EPSRC/Royal Society of Chemistry Research Chair in Bioanalytical Sciences.

Research

According to Google Scholar^[2] his most cited peer-reviewed research papers are in functional genomics,^[33] metabolomics^[34] and the yeast genome.^[35] He has also been involved in research to create a Robot Scientist^[36] in collaboration with Ross King, Stephen Muggleton and Steve Oliver as well as several projects in systems biology^{[37][38][39][40][41]}

Kell's research has been funded by the BBSRC, the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council.^[42][43]

Awards and honours

Kell was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science and research.^[20]

Kell is also a Fellow of the Learned Society of Wales (FLSW), the Society of Biology (FSB) and the American Association for the Advancement of Science (FAAAS).

References

1. KELL, Prof. Douglas Bruce. Who's Who 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
2. Douglas Kell's publications indexed by Google Scholar, a service provided by Google
3. Kell, D.; John, P.; Ferguson, S. (1978). "The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans. Magnitude, sites of generation and comparison with the phosphorylation potential". The Biochemical Journal 174 (1): 257–266. doi:10.1042/bj1740257. PMC: 1185905. PMID 212022.
4. Zelena, Eva (2009). Application of ultra performance liquid chromatography mass spectrometry to metabolic profiling of human serum and plasma (PhD thesis). University of Manchester.
5. Zelena, E.; Dunn, W. B.; Broadhurst, D.; Francis-Mcintyre, S.; Carroll, K. M.; Begley, P.; O'Hagan, S.; Knowles, J. D.; Halsall, A.; Husermet, I. D.; Wilson, D. B.; Kell, D. B. (2009). "Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum". Analytical Chemistry 81 (4): 1357–1364. doi:10.1021/ac8019366. PMID 19170513.
6. Williamson, Thomas Charles (2009). Systems studies of the cAMP pathway and Glycolytic Oscillations in Saccharomyces cerevisiae (PhD thesis). University of Manchester.
7. Williamson, T.; Schwartz, J. M.; Kell, D. B.; Stateva, L. (2009). "Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae". BMC Systems Biology 3: 70. doi:10.1186/1752-0509-3-70. PMC: 2719611. PMID 19607691.
8. Ihekwaba, Adaoha Elizabeth (2005). Modelling of cellular signal transduction process using numerical simulation techniques (PhD thesis). University of Manchester.
9. Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R. L.; Benson, N.; Kell, D. B. (2004). "Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: The roles of IKK and IkappaBalpha". Systems biology 1 (1): 93–103. doi:10.1049/sb:20045009. PMID 17052119.
10. Ihekwaba, A. E.; Broomhead, D. S.; Grimley, R.; Benson, N.; White, M. R.; Kell, D. B. (2005). "Synergistic control of oscillations in the NF-kappaB signalling pathway". Systems biology 152 (3): 153–160. doi:10.1049/ip-syb:20050050. PMID 16986278.
11. Brown, Maria Cecilia (2006). Metabolic footprinting: computational analysis of post-genomic data (PhD thesis). University of Manchester.
12. Brown, M.; Wedge, D. C.; Goodacre, R.; Kell, D. B.; Baker, P. N.; Kenny, L. C.; Mamas, M. A.; Neyses, L.; Dunn, W. B. (2011). "Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets". Bioinformatics 27 (8): 1108–1112. doi:10.1093/bioinformatics/btr079. PMC: 3709197. PMID 21325300.
13. Brown, M.; Dunn, W. B.; Dobson, P.; Patel, Y.; Winder, C. L.; Francis-Mcintyre, S.; Begley, P.; Carroll, K.; Broadhurst, D.; Tseng, A.; Swainston, N.; Spasic, I.; Goodacre, R.; Kell, D. B. (2009). "Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics". The Analyst 134 (7): 1322–1332. Bibcode:2009Ana...134.1322B. doi:10.1039/b901179j. PMID 19562197.
14. Handl, Julia Karena (2006). Multiobjective approaches to the data-driven analysis of biological systems (PhD thesis). University of Manchester.
15. Handl, J.; Kell, D. B.; Knowles, J. (2007). "Multiobjective Optimization in Bioinformatics and Computational Biology". IEEE/ACM Transactions on Computational Biology and Bioinformatics 4 (2): 279–292. doi:10.1109/TCBB.2007.070203. PMID 17473320.
16. Handl, J.; Knowles, J.; Kell, D. B. (2005). "Computational cluster validation in post-genomic data analysis". Bioinformatics 21 (15): 3201–3212. doi:10.1093/bioinformatics/bti517. PMID 15914541.
17. Mendes, Pedro Pedrosa (1994). Computer simulation of the dynamics of biochemical pathways (PhD thesis). University of Aberystwyth.
18. "AAAS - 2012 Fellows". Archived from the original on 2012-02-18.
19. "26 April 2012 - BBSRC Chief Executive elected as Fellow of the Learned Society of Wales - News - BBSRC". Archived from the original on 2012-04-27.
20. The London Gazette: (Supplement) no. 60728. p. 9. 31 December 2013.
21. "Prof Douglas Kell, research profile - personal details (The University of Manchester)". Retrieved 2012-06-12.
22. "19 June 2012 - Reappointment of Chief Executive for the Biotechnology and Biological Sciences Research Council - News - BBSRC". Archived from the original on 2012-06-26.
23. http://www.rsc.org/chemistryworld/News/2008/November/24110801.asp Douglas Kell interview
24. List of publications from Microsoft Academic Search
25. Interview with Douglas Kell on the website of the Royal Society of Chemistry
26. Douglas Kell from the Association for Computing Machinery (ACM) Digital Library
27. Douglas Kell publications from Europe PubMed Central
28. Douglas Kell on Twitter
29. Kell, D. B.; Lurie-Luke, E (2015). "The virtue of innovation: Innovation through the lenses of biological evolution". Journal of the Royal Society Interface 12 (103): 20141183. doi:10.1098/rsif.2014.1183. PMID 25505138.
30. "Hydneye House - a set on Flickr". Archived from the original on 2013-04-25.
31. "Prof Stuart Ferguson Page - Department of Biochemistry, University of Oxford". Archived from the original on 2013-04-25.
32. Kell, Douglas Bruce (1978). The bioenergetics of paracoccus denitrificans (PhD thesis). University of Oxford.
33. Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology 19 (1): 45–50. doi:10.1038/83496. PMID 11135551.
34. Goodacre, R.; Vaidyanathan, S.; Dunn, W. B.; Harrigan, G. G.; Kell, D. B. (2004). "Metabolomics by numbers: Acquiring and understanding global metabolite data". Trends in Biotechnology 22 (5): 245–252. doi:10.1016/j.tibtech.2004.03.007. PMID 15109811.
35. Oliver, S.; Winson, M.; Kell, D.; Baganz, F. (1998). "Systematic functional analysis of the yeast genome". Trends in Biotechnology 16 (9): 373–378. doi:10.1016/S0167-7799(98)01214-1. PMID 9744112.
36. King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature 427 (6971): 247–252. Bibcode:2004Natur.427..247K. doi:10.1038/nature02236. PMID 14724639.
37. Kell, D. (2009). "Journal club: A systems biologist ponders how disparate ideas can sometimes come together beautifully". Nature 460 (7256): 669–669. Bibcode:2009Natur.460..669K. doi:10.1038/460669e. PMID 19661875.
38. Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology 4: 145. doi:10.1186/1752-0509-4-145. PMC: 2988745. PMID 21029416.
39. Pir, P.; Gutteridge, A.; Wu, J.; Rash, B.; Kell, D. B.; Zhang, N.; Oliver, S. G. (2012). "The genetic control of growth rate: A systems biology study in yeast". BMC Systems Biology 6: 4. doi:10.1186/1752-0509-6-4. PMC: 3398284. PMID 22244311.
40. Douglas Kell's publications indexed by the DBLP Bibliography Server at the University of Trier
41. Douglas Kell's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
42. UK Government Grants awarded to Douglas Kell, via Research Councils UK
43. Grants awarded to Douglas Kell by the Engineering and Physical Sciences Research Council