Drug vectorization

For other uses, see Vectorization.

In pharmacology and medicine vectorization of drugs refers to (intracellular) targeting with plastic, noble metal or silicon nanoparticles or liposomes to which pharmacologically active substances are reversibly bound or attached by adsorption.[1][2]

CNRS researchers have devised a way to overcome the problem of multidrug resistance using polyalkylcyanoacrylate (PACA) nanoparticles as "vectors".[3]

Drug nanocarriers are expected to play a major role in delivering multiple drugs to tumor tissues by overcoming biological barriers.[4]

References

  1. ↑ Couvreur P. (2001). "Drug vectorization or how to modulate tissular and cellular distribution of biologically active compounds". Ann Pharm Fr 59 (4): 232–8. PMID 11468577.
  2. ↑ "Antibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs". Adv Healthc Mater. 2 (5): 718–27. 2013. doi:10.1002/adhm.201200335. PMID 23203914.
  3. ↑ http://www.cnrs.fr/Cnrspresse/en380a6.htm
  4. ↑ "Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment". Nanomedicine (Lond). 9 (10): 1499–515. 2014. doi:10.2217/nnm.14.97. PMID 25253498.

See also


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