Epstein–Barr virus nuclear antigen 2

The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is a viral protein associated with the Epstein–Barr virus.^[1]

EBNA-2 is the main viral transactivator, switching transcription from the Wp promoters initially used after infection to the Cp promoter. Together with EBNA-3C, it also activates the LMP-1 promoter. It is known to bind the host RBP-Jκ protein that is a key player in the Notch pathway. EBNA-2 is essential for EBV-mediated growth transformation.

References

↑ Palermo RD, Webb HM, Gunnell A, West MJ (August 2008). "Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2". Biochem. Soc. Trans. 36 (Pt 4): 625–8. doi:10.1042/BST0360625. PMID 18631129.

Viral proteins (early and late)

DNA

Herpes simplex	Herpes simplex virus protein vmw65 HHV capsid portal protein

Hepatitis B	HBsAg HBcAg HBeAg HBx Hepatitis B virus DNA polymerase

Epstein–Barr	EBNA-1 EBNA-2 EBNA-3 LMP-1 LMP-2 EBER

RNA

Rotavirus

Influenza

capsid:	matrix protein M1 protein viral envelope M2 protein

glycoprotein:	Influenza hemagglutinin Neuraminidase

Parainfluenza

Parainfluenza hemagglutinin-neuraminidase

Mumps

Mumps hemagglutinin-neuraminidase

Measles

Measles hemagglutinin

RSV

Respiratory syncytial virus G protein

Hepatitis C

VSPs:	E1 E2

VNPs:	P7 NS2 NS3 NS4A NS4B NS5A NS5B

Structure and genome of HIV

VSPs:	gag pol Integrase Reverse transcriptase HIV-1 protease env gp120 gp41

VRAPs:	transactivators Tat Rev Vpr Nef Vif Vpu

Fusion protein

Gag-onc fusion protein

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