ECH1
| Enoyl CoA hydratase 1, peroxisomal | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ECH1 ; HPXEL | ||||||||||||
| External IDs | OMIM: 600696 MGI: 1858208 HomoloGene: 1069 GeneCards: ECH1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1891 | 51798 | |||||||||||
| Ensembl | ENSG00000104823 | ENSMUSG00000053898 | |||||||||||
| UniProt | Q13011 | O35459 | |||||||||||
| RefSeq (mRNA) | NM_001398 | NM_016772 | |||||||||||
| RefSeq (protein) | NP_001389 | NP_058052 | |||||||||||
| Location (UCSC) |
Chr 19: 38.82 – 38.83 Mb |
Chr 7: 28.83 – 28.83 Mb | |||||||||||
| PubMed search | |||||||||||||
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[1][2][1]
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[2]
References
- 1 2 FitzPatrick DR, Germain-Lee E, Valle D (Nov 1995). "Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase". Genomics 27 (3): 457–66. doi:10.1006/geno.1995.1077. PMID 7558027.
- 1 2 "Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal".
Further reading
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Kovalyov LI, Kovalyova MA, Kovalyov PL; et al. (2006). "Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated muscle tissue.". Biochemistry Mosc. 71 (4): 448–53. doi:10.1134/S0006297906040146. PMID 16615866.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Jia Y, Qi C, Zhang Z; et al. (2004). "Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.". J. Biol. Chem. 278 (47): 47232–9. doi:10.1074/jbc.M306363200. PMID 14500732.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Filppula SA, Yagi AI, Kilpeläinen SH; et al. (1998). "Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization.". J. Biol. Chem. 273 (1): 349–55. doi:10.1074/jbc.273.1.349. PMID 9417087.