2-hydroxy-3-oxoadipate synthase

2-hydroxy-3-oxoadipate synthase
Identifiers
EC number	2.2.1.5
CAS number	9054-72-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-hydroxy-3-oxoadipate synthase (EC 2.2.1.5) is an enzyme that catalyzes the following chemical reaction:

2-oxoglutarate + glyoxylate $\rightleftharpoons$ 2-hydroxy-3-oxoadipate + CO₂

The two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

References

• Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW (1970). "Carboligase activity of alpha-ketoglutarate dehydrogenase". Biochemistry. 9 (5): 1148–53. doi:10.1021/bi00807a015. PMID 5418712.
• Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW (1968). "Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase". Biochemistry. 7 (1): 333–7. doi:10.1021/bi00841a042. PMID 4320439.
• Stewart PR and Quayle JR (1967). "The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria". Biochem. J. 102: 885–897.