Pycnoporopepsin

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Pycnoporopepsin (EC 3.4.23.30, proteinase Ia, Pycnoporus coccineus aspartic proteinase, Trametes acid proteinase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala¹⁴-Leu, Tyr¹⁶-Leu, and Phe²⁴-Phe

This enzyme is isolated from the basidiomycete Pycnoporus sanguineus.

References

↑ Tomoda, K. and Shimazono, H. (1964). "Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme". Agric. Biol. Chem. 28: 770–773. doi:10.1271/bbb1961.28.770.
↑ Tsuru, D., Hattori, A., Tsuji, H., Yamamoto, T. and Fukumoto, J. (1969). "Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis". Agric. Biol. Chem. 33: 1419–1426. doi:10.1080/00021369.1969.10859482.
↑ Ichishima, E., Kumagai, H. and Tomoda, K. (1980). "Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus". Curr. Microbiol. 3: 333–337. doi:10.1007/bf02601897.

External links

Pycnoporopepsin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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