Hydroxynitrilase
acetone-cyanhydrin lyase | |||||||||
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Identifiers | |||||||||
EC number | 4.1.2.37 | ||||||||
CAS number | 112567-89-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a hydroxynitrilase (EC 4.1.2.37) is an enzyme that catalyzes the chemical reaction
- acetone cyanohydrin cyanide + acetone
Hence, this enzyme has one substrate, acetone cyanohydrin, and two products, cyanide and acetone.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is acetone-cyanohydrin acetone-lyase (cyanide-forming). Other names in common use include alpha-hydroxynitrile lyase, hydroxynitrile lyase, acetone-cyanhydrin lyase [mis-spelt], acetone-cyanohydrin acetone-lyase, oxynitrilase, 2-hydroxyisobutyronitrile acetone-lyase, 2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming), and acetone-cyanohydrin lyase.
References
- Xu LL, Singh BK, Conn EE (1988). "Purification and characterization of acetone cyanohydrin lyase from Linum usitatissimum". Arch. Biochem. Biophys. 263 (2): 256–63. doi:10.1016/0003-9861(88)90634-0. PMID 3377504.
- Selmar D, Lieberei R, Biehl B, Conn EE (1989). "alpha-Hydroxynitrile lyase in Hevea brasiliensis and its significance for rapid cyanogenesis". Physiol. Plant. 75: 97–101. doi:10.1111/j.1399-3054.1989.tb02069.x.
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