EDF1

Endothelial differentiation-related factor 1
PDB rendering based on 1x57.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X57​
Identifiers
Symbols	EDF1 ; EDF-1; MBF1
External IDs	OMIM: 605107 MGI: 1891227 HomoloGene: 2809 GeneCards: EDF1 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • histone acetyltransferase activity • protein binding • calmodulin binding • methyltransferase activity • sequence-specific DNA binding • poly(A) RNA binding Cellular component • intracellular • nucleus • transcription factor TFIID complex • nucleolus • cytoplasm • extracellular exosome Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • multicellular organismal development • regulation of lipid metabolic process • positive regulation of DNA binding • endothelial cell differentiation • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8721	59022
Ensembl	ENSG00000107223	ENSMUSG00000015092
UniProt	O60869	Q9JMG1
RefSeq (mRNA)	NM_001281297	NM_021519
RefSeq (protein)	NP_001268226	NP_067494
Location (UCSC)	Chr 9: 136.86 – 136.87 Mb	Chr 2: 25.56 – 25.56 Mb
PubMed search

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.^[1][2][3]

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.^[3]

Interactions

EDF1 has been shown to interact with:

• Liver X receptor alpha,^[4]
• Peroxisome proliferator-activated receptor gamma,^[4] and
• TATA binding protein.^[4][5][6]

References

1. Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
2. Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053.
3. "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
4. Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
5. Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
6. Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

Further reading

• Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. PMC 358669. PMID 8164657.
• Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174.
• Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
• Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.