EHD2

EH-domain containing 2
Identifiers
Symbols	EHD2 ; PAST2
External IDs	OMIM: 605890 MGI: 2154274 HomoloGene: 22825 GeneCards: EHD2 Gene
Gene ontology Molecular function • nucleic acid binding • calcium ion binding • protein binding • ATP binding • GTP binding • hydrolase activity • protein domain specific binding Cellular component • nucleus • cytosol • plasma membrane • caveola • endosome membrane • extrinsic component of membrane • perinuclear region of cytoplasm • recycling endosome membrane • extracellular exosome Biological process • endocytosis • blood coagulation • metabolic process • cortical actin cytoskeleton organization • endocytic recycling • protein localization to plasma membrane • membrane tubulation • positive regulation of myoblast fusion • positive regulation of endocytic recycling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30846	259300
Ensembl	ENSG00000024422	ENSMUSG00000074364
UniProt	Q9NZN4	Q8BH64
RefSeq (mRNA)	NM_014601	NM_153068
RefSeq (protein)	NP_055416	NP_694708
Location (UCSC)	Chr 19: 47.71 – 47.74 Mb	Chr 7: 15.95 – 15.97 Mb
PubMed search

EH-domain containing 2, also known as EHD2, is a human gene^[1] belonging to the EHD protein family.

References

1. "Entrez Gene: EHD2 EH-domain containing 2".

Further reading

• Pohl U, Smith JS, Tachibana I; et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.". Genomics 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guilherme A, Soriano NA, Bose S; et al. (2004). "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.". J. Biol. Chem. 279 (11): 10593–605. doi:10.1074/jbc.M307702200. PMID 14676205.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Park SY, Ha BG, Choi GH; et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.". Biochemistry 43 (23): 7552–62. doi:10.1021/bi049970f. PMID 15182197.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.