EIF2A

Eukaryotic translation initiation factor 2A, 65kDa
Identifiers
Symbols	EIF2A ; CDA02; EIF-2A; MST089; MSTP004; MSTP089
External IDs	OMIM: 609234 MGI: 1098684 HomoloGene: 5969 GeneCards: EIF2A Gene
Gene ontology Molecular function • tRNA binding • translation initiation factor activity • protein binding • ribosome binding Cellular component • extracellular space • cytoplasm • eukaryotic translation initiation factor 2 complex • blood microparticle Biological process • translational initiation • regulation of translation • protein phosphorylation • positive regulation of signal transduction • SREBP signaling pathway • ribosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	83939	229317
Ensembl	ENSG00000144895	ENSMUSG00000027810
UniProt	Q9BY44	Q8BJW6
RefSeq (mRNA)	NM_032025	NM_001005509
RefSeq (protein)	NP_114414	NP_001005509
Location (UCSC)	Chr 3: 150.55 – 150.58 Mb	Chr 3: 58.53 – 58.56 Mb
PubMed search

Eukaryotic translation initiation factor 2A is a protein that in humans is encoded by the EIF2A gene.^[1][2][3]

Function

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[3] It has been shown to be important for translation initiation mediated by the HCV IRES under stress conditions by binding to the IRES domain IIId and Met-tRNA_i^Met.^[4]

See also

• eIF2

References

1. Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
2. Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews 56 (2): 291–315. PMC 372869. PMID 1620067.
3. "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
4. Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMID 21556050.

Further reading

• Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG (Nov 2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha". Molecular and Cellular Biology 22 (21): 7405–16. doi:10.1128/MCB.22.21.7405-7416.2002. PMC 135664. PMID 12370288.
• Page AB, Owen CR, Kumar R, Miller JM, Rafols JA, White BC, DeGracia DJ, Krause GS (Jul 2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta Neuropathologica 106 (1): 8–16. doi:10.1007/s00401-003-0693-2. PMID 12687390.
• Ito T, Marintchev A, Wagner G (Sep 2004). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.
• Weiser DC, Sikes S, Li S, Shenolikar S (Nov 2004). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms". The Journal of Biological Chemistry 279 (47): 48904–14. doi:10.1074/jbc.M404416200. PMID 15345721.
• Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC (Apr 2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". The Journal of Biological Chemistry 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
• Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA (Apr 2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast". Biochemical and Biophysical Research Communications 330 (1): 123–30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.
• Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S (Jun 2005). "Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways". Proceedings of the National Academy of Sciences of the United States of America 102 (26): 9200–5. doi:10.1073/pnas.0409513102. PMC 1166589. PMID 15961545.
• Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE (Jan 2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase". Proceedings of the National Academy of Sciences of the United States of America 103 (1): 63–8. doi:10.1073/pnas.0508207103. PMC 1324992. PMID 16373505.
• Squatrito M, Mancino M, Sala L, Draetta GF (Jun 2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation". Biochemical and Biophysical Research Communications 344 (3): 859–68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.
• Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ (Jul 2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". The Journal of Biological Chemistry 281 (30): 21458–68. doi:10.1074/jbc.M603784200. PMID 16717090.
• Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J (Oct 2006). "Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation". Molecular Biology of the Cell 17 (10): 4212–9. doi:10.1091/mbc.E06-04-0318. PMC 1635342. PMID 16870703.
• Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (Oct 2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". The Journal of Biological Chemistry 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686.
• Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM (Aug 2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation". The Journal of Biological Chemistry 282 (31): 22551–62. doi:10.1074/jbc.M702673200. PMID 17553788.
• Nayak R, Pintel DJ (Nov 2007). "Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA". Journal of Virology 81 (21): 11908–16. doi:10.1128/JVI.01132-07. PMC 2168773. PMID 17715234.