EIF4E3

Eukaryotic translation initiation factor 4E family member 3
Identifiers
Symbols	EIF4E3 ; eIF-4E3; eIF4E-3
External IDs	OMIM: 609896 HomoloGene: 41652 GeneCards: EIF4E3 Gene
Gene ontology Molecular function • translation initiation factor activity Cellular component • cytosol • mRNA cap binding complex Biological process • translational initiation • regulation of translation • cytokine-mediated signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	317649	66892
Ensembl	ENSG00000163412	ENSMUSG00000093661
UniProt	Q8N5X7	Q9DBB5
RefSeq (mRNA)	NM_001134649	NM_025829
RefSeq (protein)	NP_001128121	NP_080105
Location (UCSC)	Chr 3: 71.68 – 71.75 Mb	Chr 6: 99.63 – 99.67 Mb
PubMed search

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.^[1]

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.^[1][2]

Model organisms

Eif4e3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Salmonella infection	Normal[3]
Citrobacter infection	Normal[4]
All tests and analysis from[5][6]

Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3^{tm1a(KOMP)Wtsi[7][8]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[5][12] Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.^[5]

References

1. "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.
2. Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
3. "Salmonella infection data for Eif4e3". Wellcome Trust Sanger Institute.
4. "Citrobacter infection data for Eif4e3". Wellcome Trust Sanger Institute.
5. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
6. Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. "International Knockout Mouse Consortium".
8. "Mouse Genome Informatics".
9. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
10. Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
11. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
12. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.