ELAVL2

ELAV like neuron-specific RNA binding protein 2
PDB rendering based on 1d8z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1d8z​, 1d9a​, 1fnx​, 1fxl​, 1g2e​
Identifiers
Symbols	ELAVL2 ; HEL-N1; HELN1; HUB
External IDs	OMIM: 601673 MGI: 1100887 HomoloGene: 20930 GeneCards: ELAVL2 Gene
Gene ontology Molecular function • nucleotide binding • mRNA 3'-UTR binding • protein binding • poly(A) RNA binding Biological process • regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1993	15569
Ensembl	ENSG00000107105	ENSMUSG00000008489
UniProt	Q12926	Q60899
RefSeq (mRNA)	NM_001171195	NM_001177883
RefSeq (protein)	NP_001164666	NP_001171354
Location (UCSC)	Chr 9: 23.69 – 23.83 Mb	Chr 4: 91.25 – 91.4 Mb
PubMed search

ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.^[1][2]

References

1. Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID 8812435.
2. "Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Further reading

• Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. doi:10.1073/pnas.91.23.11207. PMC 45196. PMID 7972035.
• King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.". J. Neurosci. 14 (4): 1943–52. PMID 8158249.
• Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.". J. Cell. Sci. 109 (3): 579–89. PMID 8907704.
• Park S, Myszka DG, Yu M; et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.". J. Biol. Chem. 280 (13): 12690–9. doi:10.1074/jbc.M411119200. PMID 15671036.