ELAVL3

ELAV like neuron-specific RNA binding protein 3
PDB rendering based on 1d8z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1d8z​, 1d9a​, 1fnx​, 1fxl​, 1g2e​
Identifiers
Symbols	ELAVL3 ; HUC; HUCL; PLE21
External IDs	OMIM: 603458 MGI: 109157 HomoloGene: 31035 GeneCards: ELAVL3 Gene
Gene ontology Molecular function • nucleotide binding • AU-rich element binding Biological process • nervous system development • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1995	15571
Ensembl	ENSG00000196361	ENSMUSG00000003410
UniProt	Q14576	Q60900
RefSeq (mRNA)	NM_001420	NM_010487
RefSeq (protein)	NP_001411	NP_034617
Location (UCSC)	Chr 19: 11.45 – 11.48 Mb	Chr 9: 22.02 – 22.05 Mb
PubMed search

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.^[1][2]

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[2]

References

1. Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
2. "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading

• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Behrends U, Jandl T, Golbeck A; et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
• Park S, Myszka DG, Yu M; et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.". Biochem. Biophys. Res. Commun. 256 (2): 263–8. doi:10.1006/bbrc.1999.0282. PMID 10079173.
• Sakai K, Gofuku M, Kitagawa Y; et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. doi:10.1006/bbrc.1994.1358. PMID 7511893.