ELP2

Elongator acetyltransferase complex subunit 2
Identifiers
Symbols	ELP2 ; SHINC-2; STATIP1; StIP
External IDs	OMIM: 616054 MGI: 1889642 HomoloGene: 6019 GeneCards: ELP2 Gene
Gene ontology Molecular function • RNA polymerase II core binding • transcriptional repressor activity, RNA polymerase II transcription factor binding • protein kinase binding • histone binding Cellular component • histone acetyltransferase complex • cytoplasm • transcription elongation factor complex • transcriptional repressor complex • Elongator holoenzyme complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • regulation of transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • regulation of JAK-STAT cascade Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55250	58523
Ensembl	ENSG00000134759	ENSMUSG00000024271
UniProt	Q6IA86	Q91WG4
RefSeq (mRNA)	NM_001242875	NM_021448
RefSeq (protein)	NP_001229804	NP_067423
Location (UCSC)	Chr 18: 36.13 – 36.18 Mb	Chr 18: 24.6 – 24.64 Mb
PubMed search

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.^[1][2][3]

Interactions

ELP2 has been shown to interact with STAT3^[2] and Janus kinase 1.^[2]

References

1. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
2. Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A 97 (18): 10120–5. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
3. "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.