EML4

Echinoderm microtubule associated protein like 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CGC​
Identifiers
Symbols	EML4 ; C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120
External IDs	OMIM: 607442 MGI: 1926048 HomoloGene: 56841 ChEMBL: 1075114 GeneCards: EML4 Gene
Gene ontology Molecular function • molecular_function Cellular component • cytoplasm • microtubule • membrane • mitotic spindle Biological process • microtubule-based process • negative regulation of microtubule depolymerization • mitotic nuclear division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27436	78798
Ensembl	ENSG00000143924	ENSMUSG00000032624
UniProt	Q9HC35	Q3UMY5
RefSeq (mRNA)	NM_001145076	NM_001114361
RefSeq (protein)	NP_001138548	NP_001107833
Location (UCSC)	Chr 2: 42.17 – 42.33 Mb	Chr 17: 83.35 – 83.48 Mb
PubMed search

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.^[1]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.^[2]

References

1. "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
2. Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Heidebrecht HJ, Buck F, Pollmann M; et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein.". Genomics 68 (3): 348–50. doi:10.1006/geno.2000.6301. PMID 10995578.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Pollmann M, Parwaresch R, Adam-Klages S; et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation.". Exp. Cell Res. 312 (17): 3241–51. doi:10.1016/j.yexcr.2006.06.035. PMID 16890222.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.